Tinjauan Literatur: Komponen Bioaktif dan Manfaat Kesehatan Kunyit yang Berpotensi Sebagai Bahan Pangan Fungsional
Abstract
Curcuma sp., popularly known as turmeric, is a medicinal plant and spice that has long been used in traditional medicine and Indonesian cuisine. Turmeric is rich in various bioactive compounds primarily curcuminoids (curcumin, demethoxycurcumin, bisdemethoxycurcumin), flavonoids, terpenoids (ar-turmerone, α-turmerone, β-turmerone), and phytosterols that contribute to diverse pharmacological activities such as antioxidant, anti-inflammatory, anticancer, antidiabetic, hepatoprotective and antimicrobial. These active compounds can be extracted using miscellaneous conventional and modern methods, such as maceration, Soxhlet extraction, ultrasonic extraction, microwave-assisted extraction, and solvents such as ethanol, methanol, or ethyl acetate. The effectiveness of extraction is influenced by a number of factors, including solvent polarity, temperature, extraction time, and plant matrix characteristics. The purpose of this paper is to comprehensively review the main bioactive components in turmeric and their pharmacological mechanisms based on the latest scientific literature. This literature review was conducted by narrative review with systematic search by accessing Google Scholar, MDPI, ResearchGate, and ScienceDirect, focusing on scientific publications from the last ten years. The results of the study show that turmeric has broad therapeutic potential, with complex molecular mechanisms of action, although there are still challenges in terms of bioavailability and product formulation. Turmeric and its components show promising prospects as safe natural therapeutic agents, both as alternatives and as potential functional foods in the prevention and management of chronic disease.
Keywords – Bioactive Compounds, Curcuma sp., Functional Food, Health Benefits, Turmeric.
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A. W. Ningsih, I. H. Nurrosyidah, and A. Hisbiyah, ‘Pengaruh Perbedaan Metode Ekstraksi Rimpang Kunyit (Curcuma domestica) Terhadap Rendemen dan Skrining Fitokimia’, Journal of Pharmaceutical-care Anwar Medika, vol. 2, no. 2, 2018. doi http://dx.doi.org/10.36932/jpcam.v2i2.27
S. Wang, M. C. Kim, O. H. Kang, and D. Y. Kwon, ‘The Mechanism of Bisdemethoxycurcumin Enhances Conventional Antibiotics Against Methicillin-Resistant Staphylococcus aureus’, Int J Mol Sci, vol. 21, no. 21, 2020. doi https://doi.org/10.3390/ijms21217945
M. Khatun, M. A. Nur, S. Biswas, M. Khan, and M. Z. Amin, ‘Assessment of The Anti-Oxidant, Anti-Inflammatory and Anti-Bacterial Activities of Different Types of Turmeric (Curcuma longa) Powder in Bangladesh’, J Agric Food Res, vol. 6, 2021. doi https://doi.org/10.1016/j.jafr.2021.100201.
H. Fadhilah, K. Rachmani, and N. Hajaring, ‘Aktifitas Kunyit (Curcuma domestica Val.) Sebagai Antiinflamasi Ditinjau Dari Berbagai Literatur’, Edu Masda Journal, vol. 5, no. 1, 2021, doi: 10.52118/edumasda.v5i1.120.
D. Kusbiantoro and Y. Purwaningrum, ‘Pemanfaatan Kandungan Metabolit Sekunder Pada Tanaman Kunyit Dalam Mendukung Peningkatan Pendapatan Masyarakat’, Kultivasi, vol. 17, no. 1, 2018. doi: https://doi.org/10.24198/kultivasi.v17i1.15669
K. Kandiannan, M. Anandaraj, D. Prasath, T. J. Zachariah, K. S. Krishnamurthy, and V. Srinivasan, ‘Evaluation of Short and Tall True Turmeric (Curcuma longa) Varieties for Growth, Yield and Stability’, The Indian Journal of Agricultural Sciences, vol. 85, no. 5, 2015.doi 10.56093/ijas.v85i5.48514.
T. D. C. M. Vinh et al., ‘Chemical Fingerprint Analysis for Quality Assessment and Control of Curcuma longa L. Rhizomes from Vietnam Using a High-Performance Liquid Chromatography-Diode Array Detector (HPLC-DAD)’, Pharmacia, vol. 71, pp. 1–9, 2024. doi https://doi.org/10.3897/pharmacia.71.e124050
Badan Pusat Statistik Indonesia. Produksi Tanaman Biofarmaka Menurut Jenis Tanaman, 2023 [Online]. Tersedia di: https://www.bps.go.id/id/statistics-table/3/TmtaU01tVkdkazFSZHpoNFFtOHZMMVJCUzNOblVUMDkjMw%3D%3D/produksi-tanaman-biofarmaka-menurut-jenis-tanaman--2023.html?year=2023 (Diakses pada 18 Januari 2026).
S. Mattiro, Ismawati, V. Pratiwi, M. Partono, and M. J. Abdi, ‘Sosialisasi Pembuatan Jamu Kunyit Sebagai Obat Tradisional Masyarakat di Desa Belimbing Baru, Kecamatan Sungai Pinang, Kabupaten Banjar’, Jurnal Pendidikan Sosiologi Antropologi, vol. 2, no. 2, 2020. doi https://doi.org/10.20527/padaringan.v2i2.2153.
L. Fatmawati, Y. Syaiful, and K. Nikmah, ‘Kunyit Asam (Curcuma domestica Val.) Menurunkan Intensitas Nyeri Haid’, Journals of Ners Community, vol. 11, no. 1, 2020. doi https://doi.org/10.55129/jnerscommunity.v11i1.1002.
Z. M. Ramadhania, ‘Edukasi dan Pemanfaatan Herbal Sebagai Bahan Kosmetika Alami di Kecamatan Ciwaringin Kabupaten Cirebon’, Dharmakarya, vol. 7, no. 3, 2018. doi https://doi.org/10.24198/dharmakarya.v7i3.19497.
M. Nisoa, S. Kaewpradit, P. Nahar, S. Sarker, R. Charoensup, P. Puttarak, G. Yusakul, ‘Extraction of Curcumin and Curcuminoids: From Conventional Methods to Innovative Extraction Using Deep Eutectic Solvents’, Microchemical Journal, p. 114269., 2025. Doi 10.1016/j.microc.2025.114269.
N. Malahayati, T. W. Widowati, and A. Febrianti, ‘Karakterisasi Ekstrak Kurkumin dari Kunyit Putih (Kaemferia rotunda L.) dan Kunyit Kuning (Curcuma domestica Val.)’, agriTECH, vol. 41, no. 2, 2021. doi https://doi.org/10.22146/agritech.41345.
S. Laocharoen, P. Phetcharat, K. Chareekhot, and S. Nuanpeng, ‘Applying Optimized Curcumin Extraction Techniques in The Development of Novel Curcumin-Infused Products’, Applied Food Research, p. 100992. https://doi.org/10.1016/j.afres.2025.100992.
S. G. Jaiswal and S. N. Naik, ‘Turmeric Oil: Composition, Extraction, Potential Health Benefits and Other Useful Applications’, Avicenna Journal of Medical Biochemistry, vol. 9, no. 2, 2021. doi: 10.34172/ajmb.2021.15.
M. Y. Abduh, A. I. Rahmawati, T. Komariyah, and Y. Theda, ‘Solid State Fermentation of Turmeric Rhizomes with Aspergillus sp. To Improve Yield and Composition of Extracted Turmeric Oil’, IIUM Engineering Journal, vol. 24, no. 1, 2023. doi 10.31436/iiumej.v24i1.1629.
V. J. Anggraeni, D. Kurnia, D. Djuanda, and S. Mardiyani, ‘Komposisi Kimia dan Penentuan Senyawa Aktif Antioksidan dari Minyak Atsiri Kunyit (Curcuma longa L.)’, Jurnal Farmasi Higea, vol. 15, no. 1, 2023. doi 10.52689/higea.v15i1.508.
W. S. Lin, S. E. Hwang, Y. C. Koh, P. Y. Ho, and M. H. Pan, ‘Modulatory Effects of Lactobacillus paracasei-Fermented Turmeric on Metabolic Dysregulation and Gut Microbiota in High-Fat Diet-Induced Obesity in Mice’, J Agric Food Chem, vol. 72, no. 32, pp. 17924-17937., 2024. doi 10.1021/acs.jafc.4c01501.
S. A. Riyadi, F. F. Abdullah, F. Fadhilah, and N. Assidiqiah, ‘Anticancer Activity of Curcuminoids Against B16-F10 Melanoma Cell Lines’, Jurnal Ilmiah Farmako Bahari, vol. 13, no. 2, 2022.
K. Thangavel and K. Dhivya, ‘Determination of Curcumin, Starch and Moisture Content in Turmeric by Fourier Transform Near Infrared Spectroscopy (FT-NIR)’, Engineering in Agriculture, Environment and Food, vol. 12, no. 2, 2019. doi https://doi.org/10.1016/j.eaef.2019.02.003.
J. G. Ç. A. de Oliveira Filho, M. J. de Almeida, T. L. Sousa, D. C. Dos Santos, and M. B. Egea, ‘Bioactive Compounds of Turmeric (Curcuma longa L.)’, Reference Series in Phytochemistry, 2020. doi 10.1007/978-3-030-44578-2_37-1.
M. Asthariq, B. T. Dita, and F. M. Wardhani, ‘Efek Ekstrak Curcuma Zedoaria Terhadap Gula Darah Dengan Model Tikus Diabetes Tipe 2’, (Jurnal Ilmiah Mahasiswa Kesehatan Masyarakat), vol. 5, no. 4, 2020. doi 10.37887/jimkesmas.v5i4.15058.
E. M. Gloriana, L. Sagita, and S. Chempro, ‘Karakterisasi Flavonoid Daun Kitolod dengan Metode Maserasi dan Enkapsulasi’, Chempro, vol. 2, no. 2, 2023. doi https://doi.org/10.33005/chempro.v2i02.103.
V. Burman, H. Kanaujia, K. Lehari, Aastha, N. P. Singh, and Vaishali, ‘Characterization of Phenolic Compounds of Turmeric Using TLC’, J Pharmacogn Phytochem, vol. 2, 2019.
S. P. Moulick et al., ‘Nutritional Characteristics and Antiradical Activity of Turmeric (Curcuma longa L.), Beetroot (Beta vulgaris L.), and Carrot (Daucus carota L.) Grown in Bangladesh’, Heliyon, vol. 9, no. 11, 2023. doi https://doi.org/10.1016/j.heliyon.2023.e21495
S. Sepahpour, J. Selamat, M. Y. A. Manap, A. Khatib, and A. F. A. Razis, ‘Comparative Analysis of Chemical Composition, Antioxidant Activity and Quantitative Characterization of Some Phenolic Compounds in Selected Herbs and Spices in Different Solvent Extraction Systems’, Molecules, vol. 23, no. 2, 2018. doi 10.3390/molecules23020402.
K. W. Hwang, D. Son, H. W. Jo, C. H. Kim, K. C. Seong, and J. K. Moon, ‘Levels of Curcuminoid and Essential Oil Compositions in Turmerics (Curcuma longa L.) Grown in Korea’, Appl Biol Chem, vol. 59, no. 2, 2016. doi 10.1007/s13765-016-0156-9.
E. Essien, J. Newby, T. Walker, W. Setzer, and O. Ekundayo, ‘Chemotaxonomic Characterization and in-Vitro Antimicrobial and Cytotoxic Activities of the Leaf Essential Oil of Curcuma longa Grown in Southern Nigeria’, Medicines, vol. 2, no. 4, 2015. doi 10.3390/medicines2040340.
A. I. Afriani, N. Khayati, and J. E. P. Utama, ‘Pengaruh Serbuk Kunyit (Curcuma domestica Val.) Terhadap Kecepatan Reversibilitas Kesuburan Wanita Pasca Menggunakan KB Suntik DMPA’, Jurnal SMART Kebidanan, vol. 8, no. 1, 2021. doi 10.34310/sjkb.v8i1.450.
X. Li, Y. Xin, Y. Mo, P. Marozik, T. He, and H. Guo, ‘The Bioavailability and Biological Activities of Phytosterols as Modulators of Cholesterol Metabolism’, 2022. doi 10.3390/molecules27020523.
Y. Bare, ‘Analisis Senyawa Fitosterol Cymbopogon citratus dan Curcuma longa sebagai Antialzheimer’, Biopendik Jurnal Biologi, Pendidikan dan Terapan, vol. 7, no. 2, 2021. doi https://doi.org/10.30598/biopendixvol7issue2page153-159.
M. B. Tamam, N. S. Aini, A. A. A. Murtadlo, D. D. R. Turista, S. W. Naw, and Md. E. Ullah, ‘Antiviral and Anticancer Activity from Curcuma longa L. and Tamarindus indica Bioactive Compounds through In Silico Analysis’, SAINSTEK International Journal on Applied Science, Advanced Technology and Informatics, vol. 2, no. 01, 2023. doi https://doi.org/10.24036/sainstek/vol2-iss01/21.
H. Sung et al., ‘Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries’, CA Cancer J Clin, vol. 71, no. 3, 2021. doi 10.3322/caac.21660.
H. G. Gurer, O. O. Gursoy, C. Y. Eren, and C. V. Sezer, ‘Antitumor Effects of Turmeric on OVCAR-3 Ovarian Cancer Cell Lines’, Anticancer Agents Med Chem, vol. 22, no. 16, 2022. doi 10.2174/1871520622666220426103332.
A. M. T. Siregar, I. C. Lestari, I. Y. Rangkuti, and S. Oktaria, ‘Uji Efektifitas Antibakteri Ekstrak Etanol Rimpang Kunyit (Curcuma domestica Val.) Terhadap Pertumbuhan Vibrio cholera Secara In Vitro’, Jurnal Kedokteran STM (Sains dan Teknologi Medik), vol. 8, no. 1, pp. 61–71, 2025. doi https://doi.org/10.30743/stm.v8i1.801.
M. Li et al., ‘Curcumin Inhibits the Invasion and Metastasis of Triple Negative Breast Cancer Via Hedgehog/Gli1 Signaling Pathway’, J Ethnopharmacol, vol. 283, 2022. doi 10.1016/j.jep.2021.114689.
A. H. Ar Rahmah, ‘Efektivitas Rimpang Kunyit (Curcuma domestica) Terhadap Penurunan Resiko Ateroskelerosis’, Jurnal Kesehatan Masyarakat, vol. 10, no. 2, pp. 113–120, 2021.
M. N. A. Hajleh and E. A. S. Al-Dujaili, ‘Effects of Turmeric Concentrate on Cardiovascular Risk Factors and Exercise-Induced Oxidative Stress in Healthy Volunteers; An exploratory study’, Adv Pharm Bull, vol. 13, no. 3, 2023. doi 10.34172/apb.2023.052.
L. Ye et al., ‘Curcumin Analogue C66 Attenuates Obesity-Induced Myocardial Injury by Inhibiting JNK-mediated Inflammation’, Biomedicine and Pharmacotherapy, vol. 143, 2021. doi 10.1016/j.biopha.2021.112121
A. Cahyani, D. I. Anggraini, T. U. Soleha, and A. Tjiptaningrum, ‘Uji Efektivitas Antibakteri Ekstrak Rimpang Kunyit (Curcuma domestica Val.) terhadap Pertumbuhan Propionibacterium acnes In Vitro’, Jurnal Kesehatan, vol. 11, no. 3, 2020. doi https://doi.org/10.26630/jk.v11i3.2241.
D. O. Winardi et al., ‘Studi In Silico dan In Vitro Senyawa Aktif pada Rimpang Kunyit (Curcuma domestica) sebagai Antiinflamasi pada Cyclooxygenase-2 (COX-2)’, Indonesian Journal of Pharmaceutical Science and Technology, 2023. doi https://doi.org/10.24198/ijpst.v0i0.47171.
R. Meilina and R. Mukhtar, ‘Efek Antiinflamasi Ekstrak Etanol Rimpang Kunyit (Curcuma domestica Val.) pada Tikus Putih yang Diinduksi Karagenan’, Journal of Healthcare Technology and Medicine, vol. 4, no. 1, 2019. doi https://doi.org/10.33143/jhtm.v4i1.173.
R. B. Indradi, D. A. E. Pitaloka, and Suryani, ‘Network Pharmacology to Uncover Potential Anti-Inflammatory and Immunomodulatory Constituents In Curcuma longa Rhizome As Complementary Treatment in COVID-19’, Pharmacia, vol. 69, no. 4, 2022. https://doi.org/10.3897/pharmacia.69.e89799.
A. H. Suparmajid, S. M. Sabang, and R. Ratman, ‘Pengaruh Lama Penyimpanan Rimpang Kunyit (Curcuma domestica Val.) Terhadap Daya Hambat Antioksidan’, Jurnal Akademika Kimia, vol. 5, no. 1, 2017.
A. Novianto, A. Nurrochmad, and I. Puspitasari, ‘Aktivitas Hepatoprotektif Ekstrak Kunyit (Curcuma domestica Val.) dan Ekstrak Meniran (Phyllantus niruri Linn.) Pada Tikus yang Diinduksi Parasetamol: Kajian Histopatologi Liver’, Jurnal Farmasi (Journal of Pharmacy), vol. 3, no. 1, 2019. doi 10.37013/jf.v3i1.21.
H. Y. Lee et al., ‘Turmeric Extract (Curcuma longa L.) Regulates Hepatic Toxicity in A Single Ethanol Binge Rat Model’, Heliyon, vol. 8, no. 9, 2022. Doi 10.1016/j.heliyon.2022.e10737
H. Bin Lee et al., ‘Curcuma longa Rhizome Extract Activates Brown Adipocytes and Inhibits Lipogenesis in High-Fat Diet-Fed Mice’, J Funct Foods, vol. 122, 2024. doi https://doi.org/10.1016/j.jff.2024.106490.
E. S. Lee, M. H. Kwon, H. M. Kim, H. B. Woo, C. M. Ahn, and C. H. Chung, ‘Curcumin Analog CUR5–8 Ameliorates Nonalcoholic Fatty Liver Disease in Mice with High-Fat Diet-Induced Obesity’, Metabolism, vol. 103, 2020. doi 10.1016/j.metabol.2019.154015
R. Rahardjoputro, J. Santoso, and N. R. Widyaningrum, ‘Efektivitas Antibakteri Kurkumin dan Asam Tanat terhadap Staphylococcus aureus dan Escherichia coli in Vitro’, Indonesian Journal of Pharmacy and Natural Product, vol. 7, no. 1, pp. 32–40, 2024. doi https://doi.org/10.35473/ijpnp.v7i01.2997.
I. Isnawati, D. S. Hidayati, H. Herlinawati, and A. Andriana, ‘Uji Daya Hambat Ekstrak Etanol Rimpang Kunyit (Curcuma domestica Val.) terhadap Pertumbuhan Bakteri Pseudomonas aeruginosa’, Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal, vol. 12, no. 3, pp. 457–464, 2022.
M. U. Ulfah, ‘Aktivitas Antibakteri Ekstrak Aseton Rimpang Kunyit (Curcuma domestica) terhadap Bakteri Staphylococcus aureus dan Escherichia coli’, Jurnal FARMAKU (Farmasi Muhammadiyah Kuningan), vol. 5, no. 1, 2020.
A. W. Septama, A. N. Tasfiyati, R. Kristiana, and A. Jaisi, ‘Chemical Profiles of Essential Oil from Javanese Turmeric (Curcuma xanthorrhiza Roxb.), Evaluation of Its Antibacterial and Antibiofilm Activities Against Selected Clinical Isolates’, South African Journal of Botany, vol. 146, 2022.
V. Panda, A. Deshmukh, S. Singh, T. Shah, and L. Hingorani, ‘An Ayurvedic Formulation of Emblica officinalis and Curcuma longa Alleviates Insulin Resistance in Diabetic Rats: Involvement of Curcuminoids and Polyphenolics’, J Ayurveda Integr Med, vol. 12, no. 3, 2021.
V. K. Sayeli and A. K. Shenoy, ‘Antidiabetic Effect of Bio-Enhanced Preparation of Turmeric in Streptozotocin-nicotinamide Induced Type 2 Diabetic Wistar Rats’, J Ayurveda Integr Med, vol. 12, no. 3, 2021.
M. Barriga-Sánchez, G. González-Aspajo, G. Sanchez-Gonzales, C. Barreto-Salcedo, and J. A. Aranda-Ventura, ‘In Vitro and in Vivo Evaluation of Hypoglycemic Potential and Acute Toxicity of Microencapsulated Turmeric Instant Powder’, Phytomedicine Plus, vol. 4, no. 4, Nov. 2024.
S. Murugan, H. Solanki, D. Purusothaman, B. Bethapudi, M. Ravalji, and D. Mundkinajeddu, ‘Safety Evaluation of Standardized Extract of Curcuma longa (NR-INF-02): A 90-Day Subchronic Oral Toxicity Study in Rats’, Biomed Res Int, vol. 2021, 2021.
G. T. Kamsu, S. C. F. Pierre, R. S. Tagne, N. Kodjio, A. L. N. Fakam, and D. Gatsing, ‘Evaluation of the Acute and Sub-chronic Toxicity of the Ethanolic Extract of Curcuma longa (Zingiberaceae) in Wistar Albino Rats Modern Chemistry & Applications’, Modern Chemistry & Applications, vol. 7, no. 1, 2019.
DOI: http://dx.doi.org/10.36722/sst.v11i1.4639
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